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For instance, CTC-derived organoids from breast cancer patients exhibited elevated FGFR1 expression in advanced disease, promoting resistance via the NRG1–HER3 signaling axis

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Using either cisplatin sensitive or resistant established lung cancer cell lines, we showed that cisplatin induced cell death correlated with increased DNA damage induction, and although DNA repair shows important contributions to cellular resistance, it can not explain the cell viability differences among these cell lines