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IGFBP-2 also inhibited IGF-1-dependent cell proliferation, leading to a proposed model of senescence progression in keratinocytes in which IGFBP-2 upregulation contributes to p21-mediated cell cycle arrest, p16 upregulation, and further IGFBP-2 induction (247)

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Fares M, Atienza S, Grate LS, Roddy J, Bates JS , et al