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Using synthetic membranes imitating human skin or live-skin equivalents is also essential as these models eliminate the need for human or animal tests and hence improve the method’s screening potential

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Intravenous glutamine protects liver cells from oxidant injury by increasing intracellular GSH content.[71,72] The effects of oral glutamine on tumor and host GSH metabolism and response to methotrexate (MTX) have been studied in rat models of sarcoma as well as in human patients with inflammatory breast cancer