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However, the viscous semi-solid formulations may cause nasal obstruction during IN administration and reduce the nasal cavity’s formulation spreadability [31]

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The “Poptosis” Mechanism PNC-27 kills cancer cells through a four-step membrane-directed mechanism distinct from conventional apoptosis pathways: Step 1 — Target Recognition: PNC-27’s p53-derived domain (residues 12–26) adopts an HDM-2-binding conformation — confirmed by NMR structural studies to be directly superimposable on the structure of the same p53 residues when bound to HDM-2