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[DOI] [PMC free article] [PubMed] [Google Scholar] He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L (2004) Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
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The aforementioned changes result in excessive production of free radicals, which can contribute to the generation of reactive oxygen species, thus resulting in structural damage to biological systems [143,144,145]