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On the other hand, it has been reported that DIC and OGC together represent only 45–50% of the total glutathione uptake in hepatic mitochondria, so it has been proposed that the glyoxalase system contributes to mitochondrial GSH supply

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These mechanisms included suppression of oxidative stress, inflammation, and activation of stellate cells in the liver, with concomitant up-regulation of enzymes involved in detoxification and Keap1/ Nrf2/ARE pathway expression1