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Imatinib attenuated PDGFR-β pathway activity in aortas of AngII-infused Tβ4 +/Y and Tβ4 –/Y mice, confirmed by Western blotting of downstream effectors, phosphorylated AKT, and p42/p44 MAPK, expressed relative to total AKT and p42/p44 MAPK, respectively ( A )
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Understanding the role of intercellular signaling pathways and inflammatory processes occurring in adipose tissue is essential for the development of effective pharmacological agents in the complex mechanism of obesity
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