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These include T cell anergy, mediated by inhibitory receptors such as CTLA-4, clonal deletion via Fas-Fas ligand interactions, and suppression by CD4+/CD25+/Foxp3+ regulatory T cells (Tregs), which exert immunomodulatory effects through cytokines such as interleukin 10 (IL-10) and TGF-β (66, 70, 71)

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(297) identified the ALS-associated RNA-binding protein FUS as a critical regulator of antigen presentation in HMC3 microglia

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