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Failure to withdraw causes toxicity that can cause acute neurodegenerative diseases like epilepsy and hypoxia, as well as chronic neurodegenerative diseases like Alzheimer’s and Huntington’s Syndrome [190]

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A distinctive feature of CGA’s action, compared with many other polyphenols, is its ability to simultaneously modulate the Nrf2/HO-1 axis and pro-inflammatory pathways (including NF-κB and NLRP3), resulting in tissue-specific protective effects

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