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However, senkyunolides not only act on the aforementioned neurovascular targets but, more importantly, are involved in multidimensional homeostatic regulation of the neurovascular unit (by suppressing activation of the trigeminal vascular system, modulating pathological vascular alterations, modulating neurotransmitters and receptors, inhibiting inflammatory response, counteracting oxidative stress, producing analgesic effects, and improving BBB integrity) (Figure 1)

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Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W