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Chronically raised IGF-1 is its own question: in a large European cohort followed for a median of more than seventeen years, higher IGF-1 was associated with increased risk of breast and prostate cancer, and both the lowest and the highest levels carried higher all-cause mortality (a Journal of Clinical Endocrinology and Metabolism cohort study of IGF-1 and the risk of morbidity and mortality from cancer, cardiovascular disease, and all causes in EPIC-Heidelberg)