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Mechanisms of Antidiabetic Activity of Phenolics The inhibition of carbohydrate digestion by salivary and pancreatic α-amylase and α-glucosidase inhibition in the small intestine, glucose absorption inhibition, and insulin secretion stimulation and protective activity towards pancreatic β-cells against glucotoxicity damage are indicated as potential mechanisms of the hypoglycaemic action of polyphenolic compounds

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The rats were treated with GSH (250 mg/kg, ig) or levodopa ( L -dopa, 100 mg/kg, ig) plus carbidopa (10 mg/kg, ig)