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The majority of the sample were women, range 41–50 years old, Fitzpatrick IV skin type, had a family history of melasma, with daily UV exposure 3–6 hrs per day, dentofacial melasma pattern, mixed melasma type, and mild category of melasma based on MASI index (Table 1)

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pneumoniae manipulates the Toll/interleukin-1 receptor domain-containing adaptor molecule 1 (TICAM-1) to suppress MyD88- and TRIF-mediated inflammatory pathways