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Although iron is currently regarded as the sole metal ion triggering ferroptosis, accumulating evidence indicates that ferroptosis represents a metal-dependent cell death modality involving both iron and copper ( Beyond prognostic analysis, the exploration of a personalized therapeutic algorithm framework for HNSCC based on FRG/CRG also represents a potential future research direction

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Myocytes are the second major site of iron utilization, used to produce myoglobin [9] even though the mechanism of iron incorporation for myoglobin production is not well described