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Health problems that research has shown to be associated with the MTHFR genetic mutation include: ADHD Autism Anxiety Migraines Depression Colon Cancer Blood clots Thyroid issues Chronic fatigue Hormonal issues Digestive disorders Autoimmune diseases Cardiovascular disease Neural tube defects in pregnancy If you have one or more of the issues listed above, you should consider working with a functional medicine provider who can help you peel back the layers of your health to identify the root cause