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Mutation in the gene GJB1, which encodes Cx32, underlies Charcot-Marie-Tooth disease associated with CNS white matter lesions (963, 1736), whereas mutations in GJC2 (encoding Cx47) are linked to leucoencephalopathies (253) and hypomyelinating leukodystrophies known as Pelizaeus-Merzbacher disease (1774)

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