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Apart from iron, such cancer cells also require a continuous supply of adequate nutrients and oxygen available within the tumor microenvironment to generate their own bioenergetics (e.g., glucose, glutamine, cysteine, ATP, and fatty acid) and macromolecules (e.g., proteins, lipids, and nucleic acids) [10]

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doi: 10.1007/s10571-016-0380-1 133 Losada-BarreiroSSezgin-BayindirZPaiva-MartinsFBravo-DíazC