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Upon recognition of signals imparted by oxidative and electrophilic molecules, Nrf2 is released from Keap1, escapes proteosomal degradation and translocates to the nucleus to induce genes involved in defense and survival (Kensler et al., 2007)

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In conclusion, future studies on the molecular mechanism of immune stimulants and probiotics should focus on developing formulations that induce optimal and safe outcomes against WSSV