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The results of this crossover study showed the following median AUCs: 2 mg IV = 65 ng/mL × min, 2 mg SC = 23 ng/mL × min, 4 mg SC = 59 ng/mL × min and 6 mg = 249 ng/mL × min, with only the 6-mg dose differing significantly from the others ( p 5 (scale 0–10)

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Methemoglobinemia Background Methemoglobin refers to ferric form of hemoglobin (Fe3+) that is unable to bind O2 Suspect in any patient with cyanosis not responsive to supplemental O2 Consider in pediatric patient ( 5% between measurements by ABG vs pulse oximetry ("saturation gap") should raise suspicion