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Conversely, arachidonic acid itself can diffuse to vascular endothelial cells, where it can be transformed to vasoconstricting molecules such as 20-HETE ( 2 levels ( Cerebral hypoperfusion caused by a combination of abnormalities in the cerebrovascular architecture as well as non-structural alterations was suggested as a prodromal feature of AD ( Cerebral hemodynamics are also impacted in PD, with reduced CBF being reported in early stages of the disease ( Astrocyte-Neuron Energetic Coupling Efficient exchange of energy substrates between the blood and the brain is sustained by the expression of distinct transporters, including GLUT1 for glucose, MCTs for monocarboxylates (such as lactate, pyruvate and ketone bodies) and FAT for fatty acids, at the level of the BBB ( via mitochondrial oxidative phosphorylation (OXPHOS) ( Astrocyte-Neuron Lactate Shuttle (ANLS) This model, which was first introduced in the early nineties ( + /K + ATPase activation in astrocytes (to maintain Na + /K + homeostasis) with an associated energy consumption and a drop in cellular ATP levels ( Brain hypoperfusion is accompanied by reduced glucose and oxygen metabolic rates

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