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Although several candidate drug resistance mechanisms, including impaired DNA repair, decreased drug uptake, increased drug efflux and detoxification, have been proposed (reviewed by Galluzzi et al, 2012), we are still some way from understanding the molecular basis of drug resistance, and from developing biomarkers to predict the onset and monitor the development of drug-resistant disease in cancer patients

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Radiology 286 , 800–809 (2018)

chain fatty acids into the mitochondria so they can be oxidized to produce energy