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7 Therefore adjustments in dosing regimens because of hypoproteinemia or concurrent administration of highly bound drugs are not necessary except in the rare case of a drug with a high hepatic extraction ratio and narrow therapeutic index that is given parenterally (e.g., IV dosing of lidocaine)

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Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage