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They belong to the Parvoviridae family ( in vivo , all of which are essential properties of effective AAV-based gene therapy ( 6.1.1 Adeno-associated virus type 2 vector-glutamic acid decarboxylase gene therapy PD is characterised by the death of dopaminergic neurons in the SN and numerous brainstem, limbic, and midbrain neurons, resulting in changes in the activity of movement-controlling brain networks ( Furthermore, increased subthalamic nucleus (STN) activity is primarily mediated by a loss in GABAergic input from the globus pallidus in individuals with PD (Shalaby and El-Agnaf, 2022)

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