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Vitamin B12 supplementation in end stage renal diseases: a systematic review - PMC

In our case, this is particularly advantageous, since many antioxidants also have anti-inflammatory and antifibrotic properties that differ slightly (see Table 2A,B), and therefore combining them makes it possible to reduce the dose of each antioxidant (and minimize the possibility of adverse effects from an overdose) and to tackle PD and its various biochemical mechanisms, interfering in different ways with the many “chemical messengers” involved

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They are then translocated to the cytosol where they serve in the synthesis of protein and GSH, followed by a novel round of export/degradation in the apoplast [9]