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This initiates rapid activation of NF-κB and MAPK signaling, resulting in the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6) and chemokines (e.g., C-X-C Motif Chemokine Ligand 8 (CXCL8), C–C Motif Chemokine Ligand 2 (CCL2)), which recruit immune cells to irradiated tissues [65]