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Finally, some cosmetics, photosensitizing drugs (e.g., phenothiazines, sulfonamides, sulfonylureas, thiazide diuretics, tetracyclines, tricyclic antidepressants, promethazine, piroxicam), and steroid hormones (e.g., contraceptive pills, estrogen replacement therapies) increase the melanogenic effect of sun exposure and should be substituted to enable successful melasma treatment [24–27]
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Eight (8) hours because it offers a 20-30% percent concentration of oils, Perfume Dessert