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[50a] Evolutionarily conserved arginine residues at positions 104 and 232 within D2 of human CCS, together with a Gly51‐Asp52‐Asn53‐Thr54 (GDNT) motif within the disulfide loop of human SOD1, mediate stabilizing hydrogen‐bonding interactions across the heterodimer interface (Figure 4 E)

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112,113 In metastatic hormone receptor–positive breast cancer, mutations in the ligand-binding domain (LBD) of estrogen receptor 1 (ESR1), which encodes ERα, contribute to treatment resistance