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These include prolonging circulation time by avoiding rapid clearance through the reticuloendothelial system, enhancing tumor accumulation via the enhanced permeability and retention (EPR) effect, improving uptake by APCs, and controlling the release rate of encapsulated antigens or adjuvants

Bone and Joint Health

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A subset of macrophages positive for A1 was shown to be induced and localized near the lesion 1 day after the injury, suggesting a role for A1 in the pathological response to TBI (88)