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The active metal provides electrons directly to O 2 − then reduces one molecule of O 2 − and one proton to be converted to form H 2 O 2 (Figure 2)

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By reducing MDA levels and increasing SOD and GSH-Px activity, the combo therapy also strengthened antioxidant defense capacity, preventing ROS-induced lipid peroxidation, which is a significant factor in the progression of NAFLD from steatosis to NASH