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At organism-interface sites, extracellular and membrane-proximal ROS shape host defense and vascular tone: in professional phagocytes, NOX2 assembles at the phagosomal membrane to generate large bursts of O 2· − into the lumen, where rapid dismutation and the action of myeloperoxidase convert upstream oxidants into hypochlorous acid (HOCl), a potent microbicidal species that collaborates with proteases and pH control to sterilize engulfed targets (Nauseef 2019)

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