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For instance, the absence of MTM1 results in activation of mTORC1 [95] and several myotubularin-related phosphatases are reported to control different stages of autophagy, such as MTMR-14 / Jumpy controlling initiation steps in autophagosome biogenesis [96] and MTMR-3 regulating autophagosome biogenesis and size [97]
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Chronic elevations decrease insulin biosynthesis, GSIS, Ξ²-CGS and induce apoptosis
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