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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Huhn M., Nikolakopoulou A., Schneider-Thoma J., Krause M., Samara M., Peter N., Arndt T., Bäckers L., Rothe P., Cipriani A., et al