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Within the muscularis, SMCs also participate in type 2 immune responses, wherein IL-4 and IL-13-driven alternatively activated M2 macrophages promote smooth muscle hypercontractility and hypertrophy via arginase-dependent mechanisms, facilitating effective worm expulsion 181

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Investigating co-culture effects on CS-induced responses using the CFAX12 Building on previous findings that dynamic (stretch) conditions were more sensitive to CS exposure, we investigated dual and triple co-culture models to better understand the impact of CS in complex bio-models in the AX12