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Genetic deletion of tissue inhibitor of metalloproteinase-1/TIMP-1 alters inflammation and attenuates fibrosis in dextran sodium sulphate-induced murine models of colitis

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Given the vast nature of the subject treated, herein we will mostly focus on some of our recent studies 6 – 8 on the interplay between the PPP, (some) nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzymes and a recently appreciated 6 potential bridge between these pathways and damage-repair mechanisms based on non-epigenetic protein methylation