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(B) 8226/S, 8226/S-CR, 8226/S-ATOR05 control cells, as well as control cells from the indicated time points were harvested and the intracellular GSH concentration was determined as described in the Materials and Methods

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In parallel, the hyperoxidizing ER environment oxidizes the regulatory disulfide bonds in ERO1, rendering it inactive and limiting disulfide-bond formation