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Synapse targets the structural foundation of cognitive function: the density and quality of synaptic connections between neurons

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As central effectors of this system, HSPs establish an integrated cytoprotective network through multiple mechanisms: the maintenance of proteostasis, regulation of macromolecular complex assembly and disassembly (87), inhibition of heat-induced protein misfolding, facilitation of protein repair and nascent peptide folding (88), and activation of anti-infective immunity ( Figure 3d ) (89–91)