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B12 holds a rate limiting effect on two key enzymes that work within the energy cycle and the methylation cycle (Remember methylation is how we make new molecules, like myelin, creatine, DNA for news cells and break down or converts others things like hormones, toxins, serotonin to melatonin etc)

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Glutathione is one way to do that, especially in its highly bioavailable form of Setria Glutathione