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The Important Functions of GSH-Dependent Enzyme Glutaredoxin 2 (Grx2) | IntechOpen

Glutaminase inhibition then suppresses cancer cell growth, elevates intracellular ROS, and concurrently upregulates uridine phosphorylase 1 (UPP1), which promotes 5-FU conversion to its active form and thereby enhances 5-FU efficacy (171)

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doi: 10.1097/01.CCM.0000050284.35609.97 57 XingLDongWChenYDaiWXiaoXLiuZet al