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Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use — were it to become clinically available — patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation

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For tirzepatide, the same logic applies, but note whether taking tirzepatide early could be causing increased side effects