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In bacterial meningitis, changes in PCs were more strongly correlated with local CNS disease than systemic inflammation, which suggests dysfunction of the blood-CSF barrier leading to cell death

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By binding to ERα in endothelial cells, estrogens induce nitric oxide (NO) release, consequently producing vasodilation (Penotti et al., 1996), and the impedance of this flow appears to be reduced after starting hormone (estrogen) replacement therapy (HRT) ( Estrogens and Neurodegenerative Diseases Experimental and clinical data suggest that estrogens have protective effects against neurodegenerative diseases (Kumar et al., 2010