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For caffeine in particular, several epidemiological studies have also consistently shown a significant negative correlation between its consumption and a PD diagnosis 15 , although this may be explained by inverse causation (e.g., reduced caffeine consumption due its effects as central nervous system stimulant, potentially worsening PD symptoms)

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doi: 10.1111/jfbc.13267, PMID: [DOI] [PubMed] [Google Scholar] 385