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In order to quantify the morphological changes of microglia cells and astrocytes during the course of CPZ intoxication, four parameters were measured resorting to the plugin Fraclac for ImageJ (available at imagej.net/ij/plugins/fraclac/fraclac.html), through box-counting scan: (1) fractal dimension, (2) lacunarity, (3) density, and (4) convex hull area

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