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Frontiers | Metformin in polycystic ovary syndrome: unraveling multi-stage therapeutic mechanisms from puberty to long-term health outcomes

Losing sulfate in the urine reduces the sulfate available for PAPS, and therefore for every sulfation reaction downstream — including phenol and salicylate clearance

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This results in a condition not only with elevated homocysteine, but also more severe symptoms affecting the nervous system, connective tissue, muscles, and cardiovascular system