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S1P is a bioactive lipid known to induce angiogenesis [27, 28], and SPHK1 is upregulated in certain cancers such as HCC [29]

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These findings support the idea that lipid peroxidation is both a reliable marker of oxidative stress and a mechanistic factor in the development of hypertensive disorders during pregnancy, emphasizing its potential role in the cause and development of targeted treatments [32,33,34]