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The following sections will systematically elaborate on the proposed crosstalk mechanisms between ferroptosis and cuproptosis and explore corresponding synergistic therapeutic strategies, noting that many of these interactions require further experimental validation

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At the same time, Lactobacillus rhamnosus derived extracellular Vesicles can regulate the process of adipocyte metabolism, inhibit the excessive release of inflammatory factors, reduce the chronic inflammatory reaction of adipose tissue, and improve dyslipidemia (Tong et al., 2021)