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This is why honest reviews of GHK-Cu serums tend to report subtle results at best — mild brightening, slightly improved texture over months — rather than the tretinoin-tier remodeling that the in-vitro data would predict if delivery were efficient

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Lateral femoral cutaneous neuritis is characterized by abnormal skin sensations on the anterolateral 2/3 of the thigh, such as pain, numbness, burning sensation, and formant sensation, and can occur in 7–35% of patients with leg discomfort (5)