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A pharmacologic strategy for overcoming limited NAC BBB permeability and/or active efflux out of the brain includes co-administration with the membrane transporter inhibitor probenecid, a classic and promiscuous ATP-binding cassette (ABC), and solute carrier (SLC) inhibitor that blocks transport of organic acids [6]

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Doxycycline had a 1% rate of resistance compared to a 27.3% rate of resistance for sulfamethoxazole/trimethoprim and an approximate resistance rate of 50% for ticarcillin/clavulanic acid

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