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These forms of cell death contributed to the pathogenesis of COPD ( in vitro study found that treating COPD with sulforaphane can activate the antioxidant and anti-inflammatory NRF2 pathway, restoring bacterial recognition and phagocytosis in AMs ( 3.1.2 Glucose metabolism Macrophages can manifest with bidirectional metabolic changes between aerobic OXPHOS and anaerobic glycolysis in response to specific microenvironmental stimuli ( A study on AM metabolic profiles indicated that AMs in COPD exhibited a diminished capacity to dynamically compensate for mitochondrial dysfunction through increasing glycolysis
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