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While this therapy is usually effective at targeting and eliminating rapidly dividing bulk cell populations, reducing the number of circulating myeloblasts [3], this approach fails at eliminating leukemic stem cells (LSCs), which are more slowly cycling and protected in the bone marrow, where drug exposure is reduced [4]

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found that inhibiting nNOS, in combination with N-acetylcysteine (NAC), reduced THC/CBD-seeking behavior in rats, suggesting a link between nNOS and addiction mechanisms (Spencer et al