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Inducers of CYP3A4 The concomitant use of oxycodone and acetaminophen tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY ], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to oxycodone and acetaminophen tablets [see WARNINGS ]

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However, in both of these studies, the subjects enrolled were mild asthmatics who had achieved good symptom control on low doses of inhaled corticosteroids (237, 348)